Protective role of statins against ventilator-induced lung injury
نویسندگان
چکیده
منابع مشابه
Protective role of statins against ventilator-induced lung injury
experiment on the protective role of simvastatin against ventilator-induced lung injury (VILI). Th eir results are in line with those of a relevant study published recently by our research team; we also showed that pretreatment with statins (specifi cally atorvastatin) attenuates VILI [2]. By synthesizing the fi ndings of the above contributions [1,2], one could make several points. First, give...
متن کاملVentilator-induced lung injury.
From the Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and the Department of Medicine and Interdepartmental Division of Critical Care Medicine, University of Toronto — both in Toronto (A.S.S.); and Dipartimento di Anestesia e Medicina degli Stati Critici, Ospedale S. Giovanni Battista Molinette, Università di Torino, Turin, Italy (V.M.R.). Address reprint requ...
متن کاملVentilator-induced lung injury.
Severe physical-trauma can lead to the development of acute respiratory distress syndrome (ARDS). Currently, the only known treatment for ARDS is mechanical ventilation. However, if mechanical ventilation is applied inappropriately further injury and malfunction of the lungs may occur, and thus, causing a ventilator induced lung injury (VILI). VILI has several manifestations including volutraum...
متن کاملVentilator-induced lung injury.
The clinical relevance of experimental ventilator-induced lung injury has recently received a resounding illustration by the Acute Respiratory Distress Syndrome Network trial that showed a 22% reduction of mortality in patients with acute respiratory disease syndrome when lung mechanical stress was lessened by tidal volume reduction during mechanical ventilation. This clinical confirmation of t...
متن کاملRap1 mediates protective effects of iloprost against ventilator-induced lung injury.
Prostaglandin I(2) (PGI(2)) has been shown to attenuate vascular constriction, hyperpermeability, inflammation, and acute lung injury. However, molecular mechanisms of PGI(2) protective effects on pulmonary endothelial cells (EC) are not well understood. We tested a role of cAMP-activated Epac-Rap1 pathway in the barrier protective effects of PGI(2) analog iloprost in the murine model of ventil...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2010
ISSN: 1364-8535
DOI: 10.1186/cc9245